Abstract: In the process of urbanization, there is a coupling relationship between the quality of urbanization and the health of land use system. Coordinated development between those two systems will further promote the sustainable development of urbanization. This paper takes the Karst region, Guiyang city as a case study, we calculated the composite index after building the evaluation index system of urbanization quality assessment and health of land use system, and then analyzed the coordinative relationship by using the coupling coordination model and the scissors difference method. The results showed that:（1) The composite index of the urbanization quality and the health of land use system showed an upward trend year by year from 2005 to 2014, which the health of land use system changed from subhealth to elementary health to intermediate health. （2) The coupling degree between urbanization quality and the health of land use system was in antagonism status during the study period, the coupling coordination had experienced the status of nearly disorder, constrainedly harmony, and primary harmony. （3) The scissors difference of evolution rate between urbanization quality and land use system health was stable, the fluctuation tendency was gentle, which showed that those two systems maintained at a steady level. Thus, it is necessary to promote the coupling relationship between those two systems by optimizing routes