Abstract: As an effect of global climate change, extreme temperature events occur frequently in most parts of China that have serious social and environmental impacts. The Qinling-Huaihe River, an important geographical dividing line between North and South China, belongs to ecologically fragile and climate sensitive areas that are vulnerable to extreme high temperatures. Based on the daily maximum temperature, minimum temperature and average relative humidity data from 1960 to 2017 in the north and south of the Qinling-Huaihe River,the Spatiotemporal variation characteristics of high temperature and humidity in the north and south of the Qinling-Huaihe river were investigated by using the apparent temperature index, combined with ESMD (Extreme-point Symmetric Mode Decomposition) trend analysis and special spatial interpolation software for meteorological elements-ANUSPLIN. The relationship between sea surface temperature (SST) anomalies in the eastern equatorial Pacific and multi-time-scale response of high temperature and humidity were discussed using the wavelet coherence method. The results show that: (1) In terms of trend change, taking the mid-1980s and 2010 as the time node, the high temperature and humidity conditions show the characteristics of stage change in the north and south of the Qinling-Huaihe River. The north of Qinling-Huaihe River and Qinba Mountains show the trend of “descending-slowly rising-rising”, while the south of Qinling-Huaihe and Huaihe Plain show the trend of “descending-slowly rising-descending”. (2) In regard to spatial variation, the high temperature and humidity conditions in Qinling-Huaihe are characterized by “more east and less west, more south and less north”, and the influence of this pattern continues to expand northward. (3) The effect of the SST anomaly in the eastern equatorial Pacific on the northern Qinling-Huaihe River region is more significant than that in the western region. The long-term periodic scale is more stable than the short-term periodic scale. On the short-term scale of 2-8a, when the SST in the eastern equatorial Pacific Ocean is abnormally high, the high temperature and high humid weather in each region decrease. On the long-term scale of 14-16a, when the SST anomaly is high, the high temperature and humidity conditions in the lower reaches of the Yellow River and Qinba Mountains increase.