Abstract: Scientific and technological innovation is the fundamental driving force of green development. Clarifying the coupling coordination law of scientific and technological innovation and green development and the driving mechanism will help to realize the integration of regional innovation and green development. Based on the panel data of 41 cities in the Yangtze River Delta Region from 2010 to 2020, this paper quantitatively calculated the integrated development index of scientific and technological innovation and green development. The evolution characteristics and driving mechanism of the spatio-temporal pattern of the coupling and coordination of the two systems were analyzed. The results showed that: (1) The comprehensive index of scientific and technological innovation and green development level showed a slowly increasing trend. The green development level was generally ahead of the scientific and technological innovation level. (2) The coupling and coordination degree of the two systems showed s a growth trend on the whole. The number of coordinated cities increased from 14 in 2010 to 35 in 2020, among which Shanghai and Suzhou had entered the stage of high-quality coordination; Spatially, a "core-edge" feature was presented, with the high value area clustered on the "Z-shaped" axis, and the low value area decreased in a stepped pattern from east to west. (3) Various factors affected the degree of coupling coordination of the two systems. The main driving forces included economic driving force, social promoting force, market driving force, external competitiveness and government regulation. Based on this, there was a need for the Yangtze River Delta region to take advantage of the integrated development strategy, to implement innovation-driven development measures according to the local conditions, and to comprehensively enhance the green technology innovation capacity.