Abstract: County industrial agglomeration is conducive to the development of agglomeration economy externalities, and is an important way to accelerate the high-quality development of regional economy. Based on the two fundamentals of economic growth and social achievements, this paper constructed a comprehensive index system to evaluate the high-quality development level of county economy in the Shuangcheng economic Circle of Chengdu-Chongqing area. The high-quality development level of 95 counties in the Shuangcheng economic Circle from 2007 to 2021 was calculated, based on the entropy method. It was found that the high quality development level of county economy presented a spatial agglomeration trend, and there existed a significant positive correlation. On this basis, by using the spatial econometric model, the impact of county industrial agglomeration on the high-quality development of regional economy was analyzed from the spatial perspective. The results showed that: (1) the county industrial agglomeration of Shuangcheng economic Circle in Chengdu-Chongqing area demonstrated the characteristics of significant spatial dependence; (2) County industrial agglomeration significantly promoted the high-quality development of county economy in Shuangcheng Economic Circle in Chengdu-Chongqing area, but its spatial spillover effect was significantly negative, which promoted the high-quality development of county economy in the region and hindered the high-quality development of surrounding county economy. In this regard, in order to steadily promote the high-quality development of county economy, it is suggested to promote the development of industrial agglomeration, expand the radiation effect of industrial agglomeration, take advantages of the assistance and driving role of developed counties, optimize the industrial layout, and form an industrial pattern of mutual cooperation and mutual promotion.