Abstract: Based on the provincial panel data of Yangtze River Economic Belt from 2003 to 2014, this paper discusses the influence of different types of environmental regulations on international R&D spillover effect. Through the objective weighting of entropy method, building three kinds of environmental regulation indices, such as order-driven, market-driven and voluntary-driven, furtherinvestigated the influence of different types of environmental regulations on international R&D spillovers, the study shows that: (1) The environmental regulation has a “Anti-N” curve relation to the international R&D spill level. Although the types are different, showing a tendency that the international R&D spillover effect decreases first, then rises and then decreases with the increasing intensity of environmental regulation.(2) Different types of environmental regulation are heterogeneous to the international R&D spillovers. The order-driven and market-driven environmental regulation play major roles in the Yangtze River economic belt currently, and the incentive effect of voluntary participatory environmental regulation on the international R&D spillover effect has not beenfully present yet. The conclusions of this paper confirms that the “Porter hypothesis” is also established under open conditionsin someextent. Finally, according to the above-mentionedconclusions, we put forward some corresponding policy recommendations.