Abstract: Based on the data of water consumption in 16 cities of Anhui province from 2005 to 2016, the method of Social Network Analysis（SNA) is introduced to reveal the spatial correlation network structure of regional water use, and then the key areas of water management can be screened. The results show: the spatial linkages among regional water use are very close, there is no isolated urban node in the entire sample cities. During the investigated period, the network density declined slightly with a hierarchical network structure. The individual network characteristics show significant "polarization effect" and "Matthew effect". Hefei, Wuhu and Maanshan are located in the center of the network with high degree, betweenness centrality and closeness centrality, which dominate the water flow and overflow in the spatial network. At present, the regional water network in Anhui province is in the multi-core stage, which has evolved from the initial period with dual-core driving mode consists of Hefei and Maanshan-Wuhu-Tongling to the stable spatial pattern of three growth poles of Fuyang, Hefei and Maanshan-Wuhu-Tongling.