Abstract: Clarifying runoff change and its driving forces is important for the sustainable utilization of water resources in the basin. Taking the Baihe River basin as the study area, this paper analyzed the trends of multi-factors including hydrometeorological, vegetation and socio-economic factors in the study area from 1982 to 2018 based on the TFPW-MK trend test method. In addition, a Budyko framework considering the time-varying characteristics of multi-factors was constructed to quantify the contribution of various factors to runoff change. The results showed that: (1) The runoff of the Baihe River basin decreased at the rate of -2.83 mm/a in the past 37 years; the hydrothermal coupling parameter n in the Budyko framework fluctuated and increased at the rate of 0.041/10 a overall. (2) The parameter n had a high correlation with precipitation, industrial and agricultural water consumption, with the coefficient of determination (R2) of 0.97. The introduction of the time-varying parameter n can improve the runoff simulation effect. (3) Runoff in the Baihe River basin was most sensitive to precipitation and least sensitive to industrial water consumption; the contribution of precipitation to runoff reduction gradually decreased from 78.7% to 20.8% during 1991-2018, while the contribution of potential evapotranspiration and agricultural water consumption to runoff reduction gradually increased, from 7.6% and 4.1% to 17.4% and 37.5%, respectively. (4) The impact of climate change on runoff gradually decreased during the study period, with its contribution decreasing from 86.3% to 38.3%.