Abstract: Rapid urbanization has led to an decline in ecosystem servicest a hot topic on how to promote the coordination and sustainable development between urban expansion and ecological protection. studies use correlation indicators to measure the synergistic trade-offs between ecosystem services in a single period, less attention to the identification of dynamic relationships and the determination of the impact intensity. Taking Hubei Province as an example, this study measure four ecosystem services, namely water yield, food supply, maintain biodiversity and soil conservation, for the 2010 and 2020he dynamic trade-off synergy index (DESTI) to quantify the strength and direction of trade-offs and synergistic relationships among ecosystem services between 2010 and 2020he optimal parameter geo-detector to identify the driving mechanisms of the natural socio-economic factors. The results showed that: (1) from 2010 to 2020, except for habitat quality, the food supply, soil conservation, and water yield all show an increasing trend; (2) there significant spatial differences in the strength and direction of the dynamic trade-offs among the four ecosystem services; (3) the dynamic synergistic trade-offs were significantly by natural factors (sunshine hours, rainfall) and land use types, while the natural-economic interactions also the synergistic relationships. Natural-economic interactions also enhanced the spatial differences in synergistic trade-offs. This study comprehensively clarifie the spatial characteristics, intensity and driving mechanism of regional dynamic synergistic trade-offs, and propose control measures that contribute to synergistic development of regional ecology and economy.