Abstract: Based on the panel data of 31 cities in the middle reaches of the Yangtze River from 2016 to 2021, an evaluation index system was constructed to measure the development level of logistics industry and commerce industry. A coupled coordination degree model was established to measure the coordinated development level of the two industries. Dagum Gini coefficient and nuclear density estimation method were used to analyze the spatial difference degree and dynamic evolution characteristics of the coordinated development level of the two industries. The findings were as follows: (1) The development level of the commercial and trade industries lagged behind that of the logistics industry, but the development levels of both were in a positive growth trend; (2) The coordination level of the two industries was not high and was at the stage of moderate imbalance. The coupling coordination degree was in the trend of positive growth, and the coordinated development level of the two industries showed the distribution pattern of Chang-Zhu-tan metropolitan area > Wuhan metropolitan area > Nanchang metropolitan area. (3) The degree of regional differentiation of the coordinated development level showed a decreasing trend. The main source of the spatial difference of the coordinated development level was at a super-variable density, followed by intra-regional difference, and the contribution rate of inter-regional difference. (4) The coordinated development levels of the urban agglomerations and the three metropolitan areas showed an upward trend. There was no obvious polarization in Nanchang metropolitan area and Wuhan metropolitan area, while Chang-Zhu-Tan Metropolitan area showed a double-peak phenomenon at the early stage and gradually changed into a single-peak. The internal polarization tended to weaken in general.