Abstract: It is of great practical significance to study the spatio-temporal evolution characteristics and internal mechanism of the coordinated transformation and development of digitalization and greenization for promoting the high-quality economic and social development in the Middle Yangtze River region. Based on the data of A-share listed companies in Shanghai and Shenzhen stock markets from 2011 to 2020,this paper used the coupling coordination model to measure the coordination degree of dual synergy transformation and development of digitalization and greenization in 29 cities of three provinces in the Middle Yangtze River region. Kernel density estimation,Dagum Gini coefficient and spatial Durbin model were used to explore the spatio-temporal evolution,regional differences and influencing factors of the dual synergy level. The results showed that: (1) The development level of digitalization and greenization had been steadily improved,and the dual synergy level demonstrated a favourable growth trend. (2) The spatial disparity in the dual synergy level exhibited a convergence tendency,and the polarization phenomenon of three provinces displayed distinct contrasts. (3) The overall regional differences in the dual synergy level enlarged first and then reduced， and mainly came from intra-regional differences. (4) The major driving factors to promote the coordination degree of urban dual synergy were the level of economic development,the level of digital finance,the degree of informatization,the level of opening up,the level of government regulation and the level of ecological environment. This conclusion remained robust after a rigorous testing. A heterogeneity analysis was conducted on the dynamic impacts of these factors. Furthermore,the main practical paths to enhance the coordination degree of dual synergy in the study area were as follows: (1) To optimize the allocation of factors to eliminate the polarization of the dual synergy of digitalization and greenization; (2) To adopt policy guidance to narrow the regional differences of the dual synergy of digitalization and greenization; (3) To strengthen the implementation of policies based on the individual city to stimulate the internal power of the dual synergy of digitalization and greenization.