Abstract: Flooding is one of the main meteorological disasters in the Yangtze River Delta. Studies on urban flood disaster resilience can provide strong support for accelerating the construction of resilient cities and realizing high-quality regional integration development in the Yangtze River Delta. Using mandatory judgment method, entropy method and spatial autocorrelation analysis, the spatio-temporal evolution characteristics and their relevance of urban flood disaster resilience in the Yangtze River Delta were analyzed by considering four aspects (ie. society, economy, infrastructure and environment) from 2008 to 2018. The main results show that: in terms of time series, the resilience level of urban flood disaster in Yangtze River Delta showed an upward trend, and the mean value of urban resilience index increased from 0256 5 to 0354 2. The difference of resilience index among cities has increased, and the resilience level is in the stage of unbalanced development. In terms of spatial evolution pattern, the resilience level of each city in the Yangtze River Delta is obviously different, declining from center to periphery; the quantity structure of each resilience level changes from single-core distribution mode to olive-type distribution mode. Based on global spatial autocorrelation, except for 2009, the regional urban flood disaster resilience index has a positive spatial autocorrelation, but the global Moran coefficient is low, the spatial agglomeration effect is not obvious, and has experienced the change process of “dispersion-concentration-dispersion”. According to the local spatial autocorrelation, the number of cities with significant local spatial agglomeration phenomenon in urban flood disaster resilience index in the research stage accounts for about 20%, and the “low-low” type area has been dominant in the local spatial agglomeration type, and the development of regional integration needs to be improved.