Abstract: Based on the coupling and coordinated development mechanism of urban human settlements environment and digital economy, the evaluation index system of urban human settlements environment and digital economy was constructed in this paper. The spatial relationship and dynamic factors of coupling and coordination between human settlements environment and digital economy in urban agglomerations in the middle reaches of the Yangtze River and surrounding cities were studied by using entropy method, coupling coordination degree and social network analysis method. We found that: (1) The coupling and coordination level of urban human settlements environment and digital economy presented the characteristics of spatial imbalance. There existed great differences between the internal and external regions of urban agglomerations, and the coupling and coordination level of provincial capitals was more prominent; (2) Compared with the urban agglomeration around Poyang Lake, the coupling coordination correlation strength of Wuhan metropolitan area and the urban agglomeration around Changsha-Zhuzhou-Xiangtan was higher, and the external radiation driving ability was stronger; (3) Under the joint action of the central city and the surrounding cities of the urban agglomeration, the members of Hubei Province and Hunan Province were more connected and had obvious cohesion; (4) Spatial adjacency, spatial geographical distance and industrial structure were the main driving factors for the formation of the internal spatial correlation network of urban agglomerations. This study revealed the dynamic coupling and coordination relationship between human settlement environment and digital economy, which provided policy basis for improving the digital governance capacity of human settlement environment in the middle reaches of the Yangtze River urban agglomeration.