Abstract: With the advent of rapid industrialization process induces climate change and variability, flooding has become one of the most common natural hazards in the world,  there by attracting growing public concern. To understand the spatiotemporal variation of precipitation and flooding in southwest China better, this study used 98 meteorological  stations in the region during 1961-2015 to calculate precipitation intensity, precipitation persistence and precipitation degree, and further analyzed their spatiotemporal  change. The main conclusions reached are: (1) The spatial patterns of Index of total annual precipitation (PRCPTOT) and extreme precipitation indicator (R95PTOT) in southwestern  China were ‘high in the southeast and low in the northwest’. However, the spatial pattern of the CWD (Consecutive wet days) was shown to be ‘high in the southwest and low in  the northeast’. Also, the PRCPTOT decreased at the rate of 13.12 mm/10 a, and the CWD decreased at the rate of 0.29 mm/10 a while the R95PTOT increased at the rate of 1.34  mm/10 a. (2) The spatial pattern of precipitation at different level were similar, showing that ‘higher values in the southeast and lower values in the northwest’, Besides,  most highvalue concentrated in the south Yunnan, south Guizhou and near the southwest of Sichuan basin. Nevertheless, the tendency of several indices showed different trends,  the R25 (Heaviest rain days) and HD (Continuous heavy rain days) in most regions increased, while the RD (Continuous rain storm days) reduced in most of the region.  Specifically, the spatial pattern of continuous heavy rain days and rainstorm days were ‘high in the southeast, while low in the northwest’. (3)The flood intensity index in the region decreased from northeast to southwest, and for most of the study area, the rate of flood intensity tended to increase. Evidently, the area saw a negative correlation  between the flood intensity and precipitation. From the beginning of the 21st century, particularly since 2010, this region was experiencing heavy flooding. In addition,  precipitation in the southwest China declined, but the intensity of flooding was still severe. This work may help to understand regional climate change, and provide suggestions  for mitigating regional disaster.