Abstract: Considering the Ministry of Water Resources’ demands on controlling water use efficiency in the procedure of implementing the most stringent water management, the water use efficiency evaluation indicator system and the appropriate evaluation criteria, covering agricultural, industrial, households and ecological water use, were established in this paper. The entropy weight-based fuzzy matter element evaluation method and the DEA（Data Envelopment Analysis) were applied to the study of water use efficiency evaluation in the Hanjiang River Basin for 2010, 2012 and 2014. The results indicated that both methods generated identical conclusions. Compared to 2010 and 2012, the water use efficiency of 2014of all administrative regions of the study area increased remarkably, reaching the grade of medium to high. Most regions were identified as DEA invalid except Wuhan city, whose water use efficiency reached the best level. The results implied that, although these regions were implemented effective measures to improve water use efficiency, there still exists great water saving potential. Advanced water saving technology and industrial restructuring are probably needed to further improve water use efficiency. This study provided a useful management basis for effective water utilization and saving measures in Hanjiang River Basin.