Abstract: As an important starting point for realizing the strategy of rural rejuvenation, how to achieve zero growth in pesticides is central to the agricultural policy. From the perspective of investment of fine management technology, the paper attempted to analyze the impact of labor cost on behavior of farmers pesticide usage based on micro-survey data of farmers in 18 provinces. The results showed as follows: The rising labor cost has led to an increase in the amount of pesticide application for farmers who engaged in the cultivation of labor-intensive crops such as horticulture. What’s more, the investment in fine management technology will play a part of the mediating role between labor cost and pesticide application. The efficiency of pesticide application had been improved and the amount of pesticide application every time had been reduced by adding more fine management technology. At the same time, there was no significant difference among farmers with different fine-management technology inputs in the total pesticide usage, duo to relatively high number of pesticide applications for farmers facing more risk of production. Therefore, tit is necessary to support the agricultural product brand construction, develop agricultural production service organization which guides the farmers to refine the production method in order to reducing amount of pesticide usage.