Abstract: The three Gorges Reservoir Area(TGRA) has undergone significant land use change due to construction of the Three Gorges project in China, which results in a series of impacts on human economic activities and natural ecosystems. Exploring the pattern of land use pattern and its evolution in the TGRA has important theoretical value and practical significance for optimizing the territorial space pattern and innovating the regulation path of the human earth system. Hence, we used remote sensing image data of four epochs from 1990 to 2020 to investigate pattern of land use dynamics in the TGRA based on space exploration and statistical analysis. Additionally, we explored the leading driving mechanism and the path that achieve the coordination of human-earth system for the TGRA. The results showed that:(1) The main land use types for the TGRA are cultivated land(37.64%) and forest land(47.12%), while the built-up land is with the proportion of less than 2%.The ecological land such as forest land, grassland, and water area is as high as 60%.(2) Each land type for the TGRA shows obvious gradient distribution from belt-shaped center to edge, in which forest land proportion increases with more regular shape and weaker connectivity degree, while built-up land and cultivated land are fragmented but more aggregated.(3) From 1990 to 2020, the cultivated land and grassland decreased by 4.01% and 21.27%, respectively, and the forest land and built-up land increased by 2.48% and 477.4%, respectively. The degree of overall landscape fragmentation and landscape diversity have increased. Driven by humanistic and policy factors, it shows the trend of ecological restoration, which generally presents the compound transformation of the ecological economy, and the human-earth relationship also tends to be harmonious and symbiotic.(4) The ways to realize the coordination of the human-earth system in the TGRA include innovating the strategic system of “three modernizations”(systematization, intensification and efficiency), optimizing the “production-living-ecological” space, promoting the reconstruction and functional integration of regional space, and realizing the balance among quality, space and industry form; constructing a three-dimensional ecological industrialization regional integration path to promote the coupling and coordinated development of human-earth system in the reservoir area; exploring the collaborative observation system in the reservoir area, promotingnetwork monitoring, geographic engineering and intelligent decision-making; building a multi-level related management and control system for key element areas, and improving the comprehensive response ability of the regional system in multi-scale, multi-situation and multiple ways.