Abstract: In order to investigate the coordinating relationships between carbon emissions, technological innovation and green development in the Yangtze River Economic Region, 9 provinces and 2 cities were selected as the study subjects. A three-dimensional index system of carbon emissions, technological innovation and green development was constructed. The coupling coordination model, spatial autocorrelation model, obstacle model and panel Tobit model were used to investigate the coupling coordination relationship and the temporal and spatial differentiation characteristics for the period of 2012-2021. The results showed that the degree of connectivity and coordination between the provinces and municipalities in terms of carbon emissions, technological innovation and green development increased constantly during the study period. However, there existed the characteristics of asynchronous development in time and uneven development in space. There existed a significant positive correlation in space and the characteristics of spatial differentiation. There were seven major obstacles limiting the interconnected and coordinated development of the study area. The level of carbon emission, energy consumption intensity, energy consumption structure on the coupling coordination degree had a negative impact, while the level of economic development, the level of technological innovation demonstrated a positive impact. Finally, suggestions were put forward to promote the synergistic and differentiated development strategies.