Abstract: Based on panel data from 110 cities in the Yangtze River Economic Belt (YREB) from 2011 to 2021, this study constructed a comprehensive evaluation for the digital new-qualitative productivity and high-quality agricultural development in the YREB.Panel regression, coupling coordination degree models, and spatial variation function were employed to explore the coupling relationship and spatio-temporal evolution.The results indicated that there was a significant dynamic coupling relationship between the two systems.The digital new-qualitative productivity had a stronger impact on high-quality agricultural development.The mean level was in the order of the middle reaches < the upstream reaches < the downstream reaches.Regarding spatial distribution, the coupling coordination degree exhibited a spatial positive correlation globally.The high-high agglomeration areas were mainly concentrated in the Yangtze River Delta urban agglomeration and the low-low agglomeration areas were mainly in the Chengdu-Chongqing urban agglomeration and Central Guizhou urban agglomeration.The spatial randomness effect on the coupling coordination degree was gradually increasing, while the structural effect was gradually decreasing.Overall, the spatial differences were decreasing, and the local imbalances still existed.