Abstract: Digital industrialization and industrial digitization are the “double dimensions” of digital economy, and their coupling degree is of great significance to optimize the development structure of digital economy. This paper revealed and expounded the mechanism of coupling between digital industrialization and industrial digitization. A theoretical model was established to evaluate the coupling coordination degree, and an index system was designed to evaluate the coupling coordination status and trend. Based on the panel data of 11 provinces and cities of the Yangtze river economic belt from 2013 to 2018, this paper empirically analyzed the coupling coordination degree of digital industrialization and industrial digitization in the Yangtze river economic belt. The results show that the development level of digital industrialization and industrial digitization in the Yangtze river economic belt has been steadily improved, but the overall coupling coordination degree of the Yangtze river economic belt is not high and the regional gap is obvious. The digital industrialization has a tendency of lagging behind the industrial digitization. From the aspects of accelerating the development of new digital industries, and using “new infrastructure” to facilitate the digital transformation of traditional industries, and building a better system for the coordinated development of digital economy among regions and the digital transformation within regions, strengthening the cultivation and incentive of digital talents, this paper puts forward some policy suggestions to promote the integrated development of digital industrialization and industrial digitization in China.