Abstract: Taking 5 years as interval, this paper uses the average growth quantity and rate of foreign exchange earnings from tourism, applying the ESDA method, to study the spatial evolution characteristics of inbound tourism economic in 126 city-regions of Yangtze River Economic Belt from 2000 to 2015. Moreover, the spatial heterogeneity of influencing factors of inbound tourism economic is examined by the GWR method. The results show that:（1) Global Moran’s Index of tourism foreign exchange income’s average growth quantity in Yangtze River Economic Belt has experienced the changes from 0.164 6 to 0.164 1,then to 0.057 2. The agglomeration of the city-regions that share the similar increment becomes reduced. The increase of regional tourism economic tends to balance. The hottest area is always located in coastal regions in Jiangsu and Zhejiang provinces, while the coldest area that was situated in middle region moves to the north of Jiangsu, narrowing the space.（2) Global Moran’s Index of tourism foreign exchange income’s average growth rates of Yangtze River Economic Belt has experienced the changes from 0.098 6 to 0.293 1, then to 0.198 9. The correlation of tourism economic growth among city-regions is increased. And the global difference is gradually narrowing. Both coldest and hottest areas are significant changed, with the space of hot area is remarkably expanded. Finally, the number of city-regions in hot area is much more than that in cold area.（3) The growing speed of Hunan and Yunnan provinces which are used to be the most underdeveloped region is the most highest. The city-regions in Yangtze River Delta city group have always been the most active areas of inbound tourism economic growth.