Abstract: The industry-city integration demonstration zone refers to relying on the existing industrial parks, in accordance with the concept of integrated development of industry and city, accelerating the transformation of industrial parks from a single production-oriented park economy to a comprehensive urban economy. Taking the 46 national-level industry-city integration demonstration zones approved by the National Development and Reform Commission as a sample, the paper compares their differences in population attraction capacity, economic development efficiency, and environmental governance level by region. The paper applied the index evaluation method and the analytic hierarchy method to quantitatively evaluate and evaluate the development of the demonstration area from the two dimensions of development performance and integration performance. The results show that the gradient difference of “east-central-west and northeast” shows the development level of the national industry-city integration demonstration zone, while the performance of the integration of industry and city shows the characteristics of the eastern dominant, relatively balanced and basic coordination in the rest of the region. The paper concludes with suggestions for the development of the integration of industry and city in different regions.