Abstract: Based on the data of 16 cities in Hubei Province from 2005 to 2017, the spatial scale model was applied to study the impact on urbanization and industrialization level of the content of SO2, NO2 and PM10 in air. The results show that the per-capita GDP has significant negative effect on the content of SO2 in air and significant positive effect on NO2, the quantity of civil car and highway mileage have significant positive effect on SO2, NO2 and PM10 in urban air, the industrialization level has significant negative effect on SO2 and NO2 in air and significant positive effect on PM10, besides, the per-capita green space area has significant negative effect on SO2 in air and whose effect on NO2 and PM10 is not significant in the urbanization level. Therefore, it is necessary to accelerate the transformation and upgrading of industry and the development plan of it, strengthen the detection of exhaust emission of civil car in urbanization and garden construction of urban matching, establish a city green development linkage mechanism and regional inspection supervision.