Abstract: Waterfront resources are important bases for sustainable development of social economy and for maintaining ecological balance. Researching overseas experience in development and practice of large river basins has important practical significance to coordinating the relationship between protection and utilization of water front resources, as well as promoting the construction of ecological civilization and the Yangtze River protection in China. Problems and measures of comprehensive management and ecological environment protection in the Rhine basin are comprehensively analyzed in this study, and some countermeasures are put forward to promote waterfront resources along the Yangtze River development and management from aspects of attaching importance to restoring the health of Yangtze River ecosystem, innovating the organization and integrated management system of waterfront resources in the Yangtze River Economic Belt, making overall plans and coordination of waterfront space, enhancing the ecological protection and restoration of waterfront ecosystem, facilitating intensive utilization and promoting functions coordination of waterfront resources. This review expects to provide consultations for ecological protection and comprehensive management of the Yangtze River protection in China.