Abstract: Based on the perspective of human-land relationship, this study developed a theoretical analytical framework for new urbanization and urban resilience. The methodologies used included the improved entropy weight method, coupling coordination degree model, inverse distance weighting method, geo-detector model, and XGBoost-SHAP machine learning model. A systematic and comprehensive investigation into the spatio-temporal evolution patterns was conducted and the driving interaction factors of the coordinated development between new urbanization and urban resilience were explored in the Yangtze River Delta (YRD) at the municipal scale. The findings revealed that: from the temporal evolution, the overall level of coordinated development between the two systems had been steadily increasing, with the Jiangsu-Zhejiang-Shanghai region consistently leading in development, while Anhui Province demonstrates substantial potential for further advancement; From the spatial characteristics, the overall coupling coordination degree values exhibited a marked increasing trend, revealing a distinct spatial differentiation pattern characterized by lower levels in the northwest and higher levels in the southeast; Four factors were identified as the key ones that affected the value of the coupling coordination degree, which included disposable income per capita of urban residents. There existed an interaction effect among the factors. The conclusions provided theoretical reference and empirical analysis for exploring the regulatory optimization path of coordinated development of new urbanization and urban resilience in the YRD.