Abstract: It is widely agreed that the spatial infection of real estate bubble exists in China. However, it is difficult to further investigate the issue in detail by using economic methods. To demonstrate spatial infection of real estate market bubble from perspective of geography in China, we conduct a case study of 35 metropolises by developing the method of symbolic vector data, spatial autocorrelation models, and spatial interpolation model based on GIS. The results indicate that the spatial infection of real estate bubble exists between Chinese cities. Moreover, its spatial infection capability becomes stronger than before. And the capability has a hierarchy decrease from the eastern areas to northwestern areas in China. Secondly, three source cities of infection (Beijing, Shanghai, Guangzhou) is identified in 2006, but only Guangzhou is identified in 2014. It suggests that a spatial transfer of source cities of infection has happened in recent years. Finally, the government should adopt some hierarchy strategies to stop the spatial infection of real estate bubble between Chinese cities under the background of “new normal” economic.