Abstract: Based on the vegetation NDVI data, meteorological data and land use data of the growing season, trend analysis and multiple regression residual analysis are used to analyze the spatiotemporal variation characteristics of vegetation NDVI in Guizhou province from 1998 to 2018, and the relationship between vegetation NDVI and climatic factors and human activities is discussed.The results show that:(1)In Guizhou province,the annual variation of NDVI of vegetation in nearly 21a increased with a rate of 0.63×10^-2a^-1(P<0.01),and about 88.05% of the regional vegetation NDVI presented an increasing trend, while only 1.12% of the pixel presented a decreasing trend.The growth rate of vegetation NDVI in 9 cities and counties ranged from 0.84×10^-2a^-1(Liupanshui) to 0.42×10^-2a^-1(Qiandongnan).(2)In the near 21a,Qiandongnan and Guiyang are the two regions that contribute more than 50% to climate change, while seven regions contribute more than 50% to human activities and climate change, with a relatively high contribution rate of Liupanshui (73.67%), and the rest all contribute less than 70%.(3)Generally speaking, in the past 21 years,climate change has promoted vegetation in Guizhou province,and the promotion effect of human activities is greater than the inhibition effect, that is, the joint effect of climate change and human activities is the reason for vegetation restoration in most areas of Guizhou Province.