Abstract: Manufacturing reconstruing has always been a focus of academics, yet how will regional integration and greenization reshape manufacturing space needs further exploration in the context of economic transition. By reffering to the regional division index, industry specialization index, regional Gini coefficient and kernel density estimation, this paper analyzed the restructuring characteristics and driven mechanism of manufacturing in the context of regional integration and greenization based datas from counties of Jiangsu Province along the Yangtze River between 1990 to 2016.The major results were: with the deepening of regional integration and greenization, structural disparity of manufacturing was small first, then expanded and later shrinked, while sectoral homogeneity weaken first and later strengthen. Manufacturing presented an initial concentration before latter dispersal, since in early stage of regional integration "polarization" was stronger than "diffusion", while the improvment of integration and greenization brought stronger diffusion effect. Pollution-intensive chemical industry had spreaded to north of Yangtze River, areas of coastal, away from Yangtze Riverbank line as well as rural and administrative cross border districts. Regional integration and greenization, by means of an interaction involving policy flattening and environmental regulation, active expansion and passive migration of enterprises as well as technology diffusion and green innovation, had significant implications on manufacturing restructuring.