Abstract: Based on the panel data of 104 prefecture-level cities in the Yangtze River Economic Belt from 2010 to 2019, this paper used the principal component analysis to calculate the comprehensive index of informatization development and the new-type urbanization development. And then, a spatial econometric model was constructed to empirically examine the direct effect and spatial spillover effect of informatization development on the new-type urbanization. The results show that: (1) From the global regression results, the development of informatization has a significant positive impact on the new-type urbanization, while the spatial spillover effect is not obvious. Among them, information infrastructure has the greatest impact on new-type urbanization, followed by information service consumption, while the information industry has no significant impact on the development of new-type urbanization, but there is a negative spatial spillover effect. (2) From the results of subdomain regression, there are obvious spatial differences in the impact of informatization development on new-type urbanization. The upstream area has the greatest impact, followed by the middle and lower reaches. (3) Other influencing factors: Both physical capital investment and regional consumption level have a positive effect on the development of new urbanization, and there is no spatial spillover effect. The degree of opening to the outside world has no significant impact on the development of new urbanization, and there is no obvious spatial spillover effect.