Abstract: This paper used altitude, relief degree of land surface, land cover index, river network density index, temperature-humidity index, wind-chill index, degree of comfort and absolute oxygen content, for these indicators regulate biological pressures and subsistence. This paper used geographical detectors and geographically weighted regression to weigh the indicators above, and then constructed 1 km×1 km grid of the extreme environment index zone of the Qinghai-Tibet Plateau, also Identified the coordinated relationship between extreme environments and human activities. The results show that:(1)Among the indicators that have a greater impact on the distribution of villages are the land cover index, river network density index,altitude,absolute oxygen content.The comfortable period of the Qinghai-Tibet Plateau is August, and January is not suitable for human activities.(2)The results of both models present similar trend in extreme environmental index and show a trend from southeast to northwest. According to the variation of extreme environmental index, Qinghai-Tibetan plateau was categorized into the least, less, average, more, and most environmentally extreme areas. The least environmentally extreme area is the Tibet-South Valley and it accounts for the smallest area size. The less environmentally extreme areas include valleys on thefringes of high plateau and in the Hengduan Mountain areas. The areas of average extreme environmental condition include the Qaidam basin, western Sichuanplateau and southern part of the Qinghai Province. The more environmentally extreme areas are mostly the mountainous areas and account for thelargest area size. The most environmentally extreme area is the Changtang Plateau.(3)The environment and human activities in the least-less environmentally extreme areas are highly coordinated.The contradiction between the environment and human activities in average-most environmentally extreme areas is related to grazing activities, construction of engineering facilities and urbanization.