Abstract: New infrastructure has become an important carrier of industrial transformation and upgrading and high-quality economic development in the new era. In order to understand the spatial pattern and influencing factors of the coupling and coordinated development of China’s new infrastructure and industrial upgrading, this paper first constructs a comprehensive evaluation index of the development level of new infrastructure. Secondly, using the provincial panel data from 2013 to 2020, it uses TOPSIS entropy method and coupling coordination model to measure the coupling coordinative degree between new infrastructure and industrial upgrade. Then, it uses ArcGIS18.0 depicts its spatio-temporal evolution pattern, and reveal its influencing factors by using spatial econometric model. The results show that: (1) the development level of China’s new infrastructure and its three subsystems (information infrastructure, integrated infrastructure and innovative economy) is rising year by year. (2) There is great spatial heterogeneity in the development level of China’s new infrastructure. The East is higher than the national average level, and the West and northeast are relatively lagging behind.(3) From 2013 to 2020, the coupling coordinative degree between new infrastructure and industrial upgrade in all provinces in China has increased significantly, but its coupling coordination degree with industrial rationalization is higher than that with industrial intensify.(4) The coupling and coordination degree of new infrastructure and industrial upgrading is affected by many factors, such as economic development, urban scale, environmental pollution and so on. This paper studies and judges the coupling and coordinated evolution characteristics and influencing factors of China’s new infrastructure and industrial upgrading, hoping to provide decision-making reference for the interactive development of China’s new infrastructure and industrial upgrading.