Abstract: Based on analysis of the coupling mechanism and its transition mode, this paper established an evaluation index system for three systems: technology innovation, economic growth and ecological environment. Using the entropy method, coupling coordination model, spatial center of gravity model and grey prediction model, this paper scientifically measured and analyzed the spatial-temporal evolution and trend prediction of coupling coordination among technology innovation, economic growth and ecological environment in Yangtze River Delta Urban Agglomerations from 2006 to 2019. According to the research: during the study period：（1) the comprehensive level of technology innovation, economic growth and ecological environment developed favorably.（2) the level of coupling coordination of the three systems was on a steady upward trend, with a state shifting from dysfunctionality to coordination. However, there was an imbalance in the spatial distribution featuring with “center-edge” and “zigzag”. (3) the Yangtze River Delta Urban Agglomerations were characterized by a significant spatial mismatch between cities with high levels of technology innovation, economic growth and ecological environment. Therein, the technology innovation and economic growth matched best spatially, but after a period of rapid integration, it was hard to continue in deepening. （4) during the prediction period, the level of coupling coordination of the three systems continued to increase, however, partial western cities would continue to be dysfunctional in development. In order to promote the Yangtze River Delta Urban Agglomerations to achieve a higher quality of integrated development, this paper proposes corresponding suggestions for coordinated development.