Abstract: The Jialing River is the largest tributary of the Yangtze River Basin. In recent years, serious soil erosion has occurred in the Jialing River Basin. The vegetation in the Jialing River Basin has had a relatively large variance in spatial and temporal patterns, affected by the implementation of ecological protection projects and changes in climate. Studying the spatial-temporal change of vegetation coverage and its driving factors in the Jialing River Basin can provide reference for the ecological environment management. This study, based on MODIS-NDVI and climate data, aims to analyze the spatial-temporal change of vegetation coverage and its driving factors in the Jialing River Basin between 2000 and 2019 from multiple angles. Linear regression, Hurst index, coefficient of variation and were employed. AND Mann-Kendall test with partial correlation are both used to investigate the spatiotemporal change of vegetation coverage and its relationship with climate change. The results show that: (1) In the past 20 years, the NDVI of the study area are increased, with a linear tendency being 2.9%/10a, and there is a significant difference in the spatial distribution, showing that the upper and middle reaches are higher and the lower reaches are lower; (2) The vegetation coverage improved area was larger than the degraded area, being 88.68% and 11.32% respectively in the 20 years, The specific manifestation is a significant increase in the southern part of Longnan and southern Shanxi and the eastern part of the middle and lower reaches, and a decrease in the northwest and southern cities, counties and urban areas of the basin; (3) The fluctuation of vegetation coverage in the northern part of the basin is stronger than that in the southern part, and the fluctuation in the central and eastern part is the smallest; (4) The reverse characteristic of vegetation coverage change is significant. In future, the vegetation change showed a continuous degradation trend mainly in southern Luqu County and the southern cities of the basin, and the continuous improvement trend was mainly in Jiange County and Cangxi County of Guangyuan City. The rest of the area showed a trend from degradation to improvement; (5) Temperature has the greatest impact on the change of vegetation coverage in the Jialing River Basin, and there is a time lag effect on the response of vegetation NDVI to temperature and precipitation. The impact of human activities on the change of vegetation coverage is two-sided.