Abstract: Green technology innovation is one of the important ways to promote regional high-quality development. Based on the panel data of 41 cities at prefecture level and above in Yangtze River Delta region from 2011 to 2019, this paper analyzes the spatio-temporal pattern of industrial carbon dioxide emission and green technology innovation level in Yangtze River Delta region by using ArcGIS spatial analysis and spatial Durbin model, and empirically examines the spatial effect of green technology innovation on industrial carbon dioxide emission. The results show that: (1) Industrial carbon dioxide emissions are at a high level, slightly fluctuating and rising, showing a pattern of high in the east and low in the west, high in the north and low in the south, while the scale of green technology innovation increases year by year, first slowly and then rapidly, showing a pattern of high in the east and low in the west, and the “anti K-shaped” spatial pattern has begun to take shape. (2) The impact of green technology innovation on carbon emissions has a significant spatial transmission effect, and the increase of green technology innovation level of adjacent cities in geographical space and economic geographical space will promote the carbon emission reduction of local cities. (3) Independent green technology innovation has significant effect on restraining industrial carbon emissions. The restraining effect of green technology innovation from neighboring cities on industrial carbon emissions is greater than the promoting effect of green technology innovation in local cities on industrial carbon emissions. Cooperative green technology innovation has no significant effect on industrial carbon emission reduction due to its small scale.The key points to further promote the low-carbon green development of Yangtze River Delta are to deeply explore the coordination, joint defense and control mechanism among cities in the Yangtze River Delta region in promoting carbon emission reduction, and strengthen the construction of regional green technology collaborative innovation network.