Abstract: Economic resilience refers to the ability of cities and regions to quickly absorb, recover and maintain normal economic operation when they suffer from shocks. This is crucial towards the realization of high-quality regional development strategies. Based on the impact cycle, this paper divided regional economic resilience into long-cycle and short-cycle economic resilience, and measured the level of long-cycle economic resilience of the urban agglomeration in the middle reaches of the Yangtze River. The spatio-temporal evolution characteristics of economic resilience were also analyzed in terms of temporal and spatial evolution pattern. The corresponding influencing factors were further identified. The results showed that: （1) There were significant spatial differences in the economic resilience in the study area.(2）The main influencing factors of short-cycle economic resilience varied with the impact type and development stage. The government governance ability had a positive and lasting effect on economic resilience.(3)The influencing factors of long-cycle economic resilience demonstrated a certain stability and regularity. The innovation ability and labor status were the core factors affecting economic resilience. The factors such as economic development foundation, foreign trade and government governance ability also played an important role in regional economic resilience. These outcomes may provide a reference for grasping the law of economic resilience development and for improving the level of regional economic resilience.