Abstract: Integrating the concept of high-quality development into urban land use, and based on the panel data of 41 cities in the Yangtze River Delta from 2010 to 2020, we explored the spatial and temporal pattern characteristics of high-quality use of urban land (HUUL) by using the comprehensive evaluation model and exploratory spatial data analysis. We analyzed the spatial interaction effect and driving factors of HUUL in the Yangtze River Delta by using the spatial Durbin model and partial differential method. The results show that: (1) From 2010 to 2020, the HUUL level in the Yangtze River Delta region showed a continuous growth trend, while the spatial differentiation was significant. The cities along the Yangtze River and the coastal cities around Hangzhou Bay had higher HUUL levels, while the western region of the Yangtze River Delta had lower HUUL levels. (2) The level of HUUL in the Yangtze River Delta region showed a significant positive global spatial autocorrelation. The local space was characterized by High-High and Low-Low concentration types. The spatial interaction effect of HUUL among cities were significant. (3) Infrastructure, technological innovation, and government management were the important driving factors that affected the HUUL spatial interaction effect among cities, while Economic level and industrial structure only affected the local cities’ HUUL, and the spillover effect on neighboring cities was not significant. The level of informatization had significant positive promotion effects on the HUUL of neighboring cities. The research results are of great significance for revealing the internal mechanism of HUUL spatial interaction effect and for guiding the Yangtze River Delta region to improve the quality of urban land use from the perspective of regional linkage.