Abstract: Based on the panel data of comprehensive well-being, resource and environmental pressure and economic growth of cities in the Yangtze River Delta from 2000 to 2017, the spatial variogram function, panel vector auto-regression and panel gray correlation model were used to explore the spatio-temporal evolution, impulse response and correlation characteristics between the three. The results indicate that: (1) Urban  comprehensive well-being, resource and environmental pressure and economic growth of cities in the Yangtze River Delta have showed continuous upward evolution, and the regional differentiation between cities tends to continue to decline. (2) urban comprehensive well-being, resource and environmental pressure, and economic growth have long-term interaction effects, and the impulse response between the three has a time-series cumulative effect, while resource and environmental pressure and urban comprehensive well-being have no causal relationship, and there is a one-way causal relationship between economic growth and urban comprehensive well-being. causal relationship. (3) The panel grey correlation reveals that the spatial correlation coefficient of economic growth and urban comprehensive well-being is relatively high, showing a differentiated pattern of high in the east and low in the west, while the spatial correlation coefficient of between urban comprehensive well-being, economic growth and resource and environment pressure shows a spatial dislocation phenomenon with higher correlation intensity distributed in economically underdeveloped cities and lower correlation intensity distributed in developed cities. And, the general correlation intensity between the three tends to fluctuate and decrease with time.