Abstract: The coordinated development of the Yangtze River economic belt has undertaken an important mission in building a new development pattern. Based on the traditional driving forces of regional development transformation, building the new development pattern will inject new dynamics into the coordinated development of the Yangtze River economic belt from three aspects of endogenous, exogenous, and incentive. To effectively solve the new challenges and problems such as the stark inequality of regional development and its factor flow, the synchronization of industrial upgrading with infrastructure construction and land space optimization, the collaborative governance of ecological environment and the coordinated mechanism between regional plates and urban clusters, the economic belt must put forward the promotion path including realize the cooperation of industrial development by jointly building industrial park facilities, share development opportunities by integrating the spatial layout of land, jointly undertake rights and responsibilities and then realize the coordinated protection of ecological environment, negotiate the interests of different subjects by jointly designing systems and mechanism, establish the consciousness of regional community and create a new model of regional coordinated development.