Abstract: The metropolitan area is a new form of promoting new urbanization, and it is also the basic unit to realize the regional economic development. This study clarifies the key role of the comprehensive competitiveness of cities and towns, the intensity of spatial connection and the inter-regional flow of elements in the core system of the metropolitan area in the process of regional spatial development. Through the comprehensive comparison of the metropolitan area, in order to optimize the new mechanism of regional coordinated development, To meet the new requirements of improving quality and increasing efficiency in metropolitan area to provide new reference. Combined with the comprehensive competitiveness model of cities and towns, the improved spatial relationship model and the factor flow intensity model, this paper analyzes the Changsha metropolitan area and Wuhan metropolitan area in the middle reaches of the Yangtze River in 2016. The comparative differences of Nanchang metropolitan area in three dimensions: urban comprehensive competitiveness, spatial structure and urban function division system. The conclusions are as follows: (1) the research on comprehensive competitiveness of each metropolitan area shows that the comprehensive competitiveness of each metropolitan area has significant spatial disequilibrium distribution characteristics, Changsha metropolitan area is developed in the east-west axis zone, the difference between the center and the peripheral towns of Wuhan metropolitan area is significant, and the Nanchang metropolitan area lacks a high value development center with strong leading ability; (2) Changsha metropolitan area forms the circular spatial structure form from the center to the periphery, Wuhan metropolitan area forms the multi-center group spatial structure form, Nanchang metropolitan area presents the Changjiu “double star” spatial structure form. The urban circle has a significant difference in the directivity and spatial structure of the central city, and is associated with the factors such as the urban expansion policy, the urban development gap and the network of the modern transportation line. With the perfect function division system of element flow, the matching degree between traffic flow and economic flow in Wuhan city circle is poor, and the urban circle of Nanchang lacks perfect economic flow and traffic flow function division system; (4) In the discussion and analysis, the city circle points out the perfect resource sharing and the element transfer channel, the construction of the urban economic cooperation mechanism, the promotion of the development of the modern transportation network system, etc. Development ideas.