Abstract: It is significant to objectively evaluate the employment situation brought about by the development strategy of the Yangtze River Economic Belt and clarify the influence of the strategy on the employment in order to promote a green and high-quality development and achieve a fuller employment in the area of Yangtze River Economic Belt. Based on the panel data of 268 prefecture-level cities across the country from 2009 to 2017, this paper first uses the difference-in-differences model (DID) to evaluate the net effect of this development strategy on the employment in the area of the Yangtze River Economic Belt；then the multiple intermediary effect model is used to empirically test the impact mechanism of the development strategy of the Yangtze River Economic Belt on employment. It is found that：(1) the development strategy of Yangtze River Economic Belt has significantly promoted the employment in the areas covered by the Yangtze River Economic Belt, which has been proved valid by a series of robustness tests；(2) the development strategy of Yangtze River Economic Belt promotes the employment in the area of the Yangtze River Economic Belt by means of three paths, that is, promoting industrial transformation and upgrading, building comprehensive three-dimensional transportation corridors, and increasing ecological and environmental protection. Governments at all levels should continue to implement and improve the development strategy of the Yangtze River Economic Belt, strengthen industrial transformation and upgrading, accelerate the construction of comprehensive three-dimensional transportation corridors, solidly promote ecological and environmental protection, and jointly stabilize the overall employment situation in the area of Yangtze River Economic Belt.