Abstract: Ecological risk assessment on urban agglomeration scale is one of the problems urgently needed to be studied.Chengdu-Chongqing urban agglomeration is taken as the research area. Based on the GlobeLand30 data set of 2000, 2010 and 2020, landscape ecological risk index is introduced. From the perspective of landscape ecology, geostatistics and GIS software are used to carry out spatial analysis, combined with semi-variational function and spatial autocorrelation analysis method.The change of landscape pattern in Chengdu-Chongqing urban agglomeration was analyzed and its ecological risk was evaluated.The results showed that: (1) construction land increased year by year in chengdu-chongqing urban agglomeration, while the total area of cultivated land and grassland decreased, and cultivated land reclamation existed; (2) The spatial distribution of landscape types in chengdu-Chongqing urban agglomeration becomes complicated and fragmented; (3) The overall ecological risk index of Chengdu-Chongqing urban agglomeration showed an increasing trend, and the area of high ecological risk area and high ecological risk area gradually expanded.The results of this study provide reference for land use allocation and ecological security pattern construction in this region.